醫師學術論文
Paper李建緯 Chien-Wei Lee 副主任
李建緯博士為國立陽明交通大學博士,先於香港中文大學任教,110年10月獲邀加入本院團隊。主要研究方向為幹細胞分化潛能及結合組織工程技術在肝臟、骨骼肌肉疾病與抗衰老治療的機制探討和臨床轉化應用。目前已發表多篇同行評議期刊,包括Gastroenterology、Journal of Advanced Research、 Free Radical Biology and Medicine、Stem Cell Reports、Translational Research。專長為:幹細胞生物學、間質幹細胞治療、組織工程與再生醫學於骨骼肌肉系統之應用、老化研究等。
相關連結
學術機構典藏
論文
期刊論文
期刊論文/Journal Paper (作者群,論文題目,期刊名稱,出版年月,卷號(期別):頁次起迄) |
日期 | |
1 | (Xiaobo Zhu)、(Mingde Cao)、(Kejia Li)、(Yau-Tsz Chan)、(Hon-Fai Chan)、(Yi-Wah Mak)、(Hao Yao)、(Jing Sun)、李建緯(LEE CHIEN-WEI)、(Yangzi Jiang)*,Intra-articular sustained-release of pirfenidone as a disease-modifying treatment for early osteoarthritis,Bioactive Materials,2024 May,39():255-272 | 2024 . 05 |
2 | (Hao Zhang)、(Wenjing Yan)、(Jinhui Wang)、(Shuqian Xie)、(W. Andy Tao)、李建緯(LEE CHIEN-WEI)、(Xing Zhang)、(Hongtao Xu)*、(Jiang Xia)*、(Shizhi Wang)*,Surface functionalization of exosomes for chondrocyte-targeted siRNA delivery and cartilage regeneration,JOURNAL OF CONTROLLED RELEASE,2024 Apr,6(369):493-505 | 2024 . 04 |
3 | (Wei-Ting Lin)、吳浩翔(WU HAO-HSIANG)、李建緯(LEE CHIEN-WEI)、陳瑜帆(CHEN YU-FAN)、(Lawrence Huang)、何慧君(HO HUI-CHUN)*、李光申(Oscar Kuang-Sheng Lee)*,Modulation of experimental acute lung injury by exosomal miR-7704 from mesenchymal stromal cells acts through M2 macrophage polarization,Molecular Therapy-Nucleic Acids,2024 Mar,35(1): | 2024 . 03 |
4 | (Zihao Wan)、陳瑜帆(CHEN YU-FAN)、(Qi Pan)、(Yiwei Wang)、Shuai Yuan、(Hui Yen Chin)、吳浩翔(WU HAO-HSIANG)、(Wei-Ting Lin)、(Yun-Jung Yang)、鄭柏裕(CHENG PO-YU)、(Shekhar Madhukar Kumta)、李建緯(LEE CHIEN-WEI)*、李光申(Oscar Kuang-Sheng Lee)*,Single-cell transcriptome analysis reveals the effectiveness of cytokine priming irrespective of heterogeneity in mesenchymal stromal cells,CYTOTHERAPY,2023 Sep,14(23):1465-3249 | 2023 . 09 |
5 | (Belle Yu-Hsuan Wang)、(Allen Wei-Ting Hsiao)、(Hoi Ting Shiu)、(Nicodemus Wong)、(Amanda Yu-Fan Wang)、李建緯(LEE CHIEN-WEI)*、李光申(Oscar Kuang-Sheng Lee)*、(Wayne Yuk-Wai Lee)*,Mesenchymal stem cells alleviate dexamethasone-induced muscle atrophy in mice and the involvement of ERK1/2 signalling pathway,Stem Cell Research & Therapy,2023 Aug,14(1):195 | 2023 . 08 |
6 | (Belle Yu-Hsuan Wang)、(Yi-Fan Chen)、(Allen Wei-Ting Hsiao)、(Wan-Jing Chen)、李建緯(LEE CHIEN-WEI)*、李光申(Oscar Kuang-Sheng Lee)*,Ginkgolide B facilitates muscle regeneration via rejuvenating osteocalcin-mediated bone-to-muscle modulation in aged mice,Journal of Cachexia Sarcopenia and Muscle,2023 Apr,14(3):1349-1364 | 2023 . 04 |
7 | (Belle Yu-Hsuan Wang)、(Allen Wei-Ting Hsiao)、(Nicodemus Wong)、(Yi-Fan Chen)、李建緯(LEE CHIEN-WEI)*、(Wayne Yuk Wai Lee)*,Is dexamethasone-induced muscle atrophy an alternative model for naturally aged sarcopenia model?,Journal of Orthopaedic Translation,2023 Mar,39():12-20 | 2023 . 03 |
8 | (Hongtao Xu)、(Yanlun Zhu)、(Allen Wei-Ting Hsiao)、(Jiankun Xu)、(Wenxue Tong)、(Liang Chang)、(Xuerao Zhang)、(Yi-Fan Chen)、(Jie Li)、(Wei Chen)、(Yingze Zhang)*、(Hon Fai Chan)*、李建緯(LEE CHIEN-WEI)*,Bioactive glass-elicited stem cell-derived extracellular vesicles regulate M2 macrophage polarization and angiogenesis to improve tendon regeneration and functional recovery,BIOMATERIALS,2023 Mar,294():121998 | 2023 . 03 |
9 | 陳瑜帆(CHEN YU-FAN)、李建緯(LEE CHIEN-WEI)、(Hao-Hsiang Wu)、(Wei-Ting Lin)、李光申(Oscar Kuang-Sheng Lee)*,Immunometabolism of Macrophages Regulates Skeletal Muscle Regeneration,Frontiers in Cell and Developmental Biology,2022 Sep,6(): | 2022 . 09 |
10 | 李建緯(LEE CHIEN-WEI)、(Yi-Fan Chen)、(Allen Wei-Ting Hsiao)、(Amanda Yu-Fan Wang)、(Oscar Yuan-Jie Shen)、(Belle Yu-Hsuan Wang)、(Lok Wai Cola Ho)、(Wei-Ting Lin)、(Chung Hang Jonathan Choi)、李光申(Oscar Kuang-Sheng Lee)*,Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells,Journal of Advanced Research,2022 Jul,39():73-88 | 2022 . 07 |
11 | (Wan-Jing Chen)、(I-Hsuan Lin)、李建緯(LEE CHIEN-WEI)、(Kiyoshi Yoshioka)、(Yusuke Ono)、(Yu-Ting Yan)、(Yun Yen)*、(Yi-Fan Chen)*,Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle,npj Regenerative Medicine,2022 Jul,7(7):37 | 2022 . 07 |
12 | (Hongtao Xu)、(Yanlun Zhu)、(Jiankun Xu)、(Wenxue Tong)、(Shiwen Hu)、(Yi-Fan Chen)、(Shuai Deng)、(Hao Yao)、(Jie Li)、李建緯(LEE CHIEN-WEI)*、(Hon Fai Chan)*,Injectable bioactive glass/sodium alginate hydrogel with immunomodulatory and angiogenic properties for enhanced tendon healing,Bioengineering & Translational Medicine,2022 May,():e10345 | 2022 . 05 |
13 | (Carol P. Y. Lau)、(Wenao Ma)、(Kwan Yau Law)、(Maribel D. Lacambra)、(Kwok Chuen Wong)、李建緯(LEE CHIEN-WEI)、李光申(Oscar Kuang-Sheng Lee)、Qi Dou(Qi Dou)*、(Shekhar M. Kumta)*,Development of deep learning algorithms to discriminate giant cell tumors of bone from adjacent normal tissues by confocal Raman spectroscopy,ANALYST,2022 Jan,147(7):1425-1439 | 2022 . 01 |
14 | (Oscar Yuan-Jie Shen)、(Yi-Fan Chen)、(Hong-Tao Xu)、李建緯(LEE CHIEN-WEI)*,The Efficacy of Naïve versus Modified Mesenchymal Stem Cells in Improving Muscle Function in Duchenne Muscular Dystrophy: A Systematic Review,Biomedicines,2021 Aug,9(9):1097 | 2021 . 08 |
15 | (Rita Lih-Ying Shin)、李建緯(LEE CHIEN-WEI)、(Oscar Yuan-Jie Shen)、(Hongtao Xu)、李光申(Oscar Kuang-Sheng Lee)*,The Crosstalk between Mesenchymal Stem Cells and Macrophages in Bone Regeneration: A Systematic Review,Stem Cells International,2021 Jun,2021(): | 2021 . 06 |
16 | (Xiaobo Zhu)、李建緯(LEE CHIEN-WEI)、(Hongtao Xu)、(Yu-Fan Wang)、(Patrick S. H. Yung)、(Yangzi Jiang)、李光申(Oscar Kuang-Sheng Lee)*,Phenotypic alteration of macrophages during osteoarthritis: a systematic review,ARTHRITIS RESEARCH & THERAPY,2021 Apr,2021(23):110 | 2021 . 04 |
17 | 李建緯(LEE CHIEN-WEI)、(Hui-Chu Lin)、(Belle Yu-Hsuan Wang)、(Amanda Yu-Fan Wang)、(Rita Lih-Ying Shin)、(Stella Yee Lo Cheung)、李光申(Oscar Kuang-Sheng Lee)*,Ginkgolide B monotherapy reverses osteoporosis by regulating oxidative stress-mediated bone homeostasis,FREE RADICAL BIOLOGY AND MEDICINE,2021 Mar,168(2021):234-246 | 2021 . 03 |
18 | (Wan-Jing Chen)、(I-Hsuan Lin)、李建緯(LEE CHIEN-WEI)、陳怡帆(Yi-Fan Chen)*,Aged Skeletal Muscle Retains the Ability to Remodel Extracellular Matrix for Degradation of Collagen Deposition after Muscle Injury,INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2021 Feb,22(4):2123 | 2021 . 02 |
19 | (Zihao Wan)、(Lih-Ying Shin)、(Yu-Fan Wang)、(Zhihao Huang)、(Yanjing Dong)、李建緯(LEE CHIEN-WEI)、(Shekhar-Madhukar Kumta)、李光申(LEE KUANG-SHENG)*,Role of skeletal macrophages in fracture repair: A systematic review,BIOMEDICAL REPORTS,2020 Dec,13(6):53 | 2020 . 12 |
20 | (Hongtao Xu)、李建緯(LEE CHIEN-WEI)、(Yu-Fan Wang)、(Shuting Huang)、(Lih-Ying Shin)、(Yu-Hsuan Wang)、(Zihao Wan)、(Xiaobo Zhu)、(Patrick Shu Hang Yung)、李光申(LEE KUANG-SHENG)*,The Role of Paracrine Regulation of Mesenchymal Stem Cells in the Crosstalk With Macrophages in Musculoskeletal Diseases: A Systematic Review,Frontiers in Bioengineering and Biotechnology,2020 Nov,8():587052 | 2020 . 11 |
21 | (Zihao Wan)、李建緯(LEE CHIEN-WEI)、(Shuai Yuan)、李光申(LEE KUANG-SHENG)*,Can p63 serve as a biomarker for diagnosing giant cell tumor of bone? A systematic review and meta analysis,Sao Paulo Medical Journal,2020 Oct,138(5):393-399 | 2020 . 10 |
22 | (Ching-Hsuan Hu)、(Yi-Wen Tseng)、李建緯(LEE CHIEN-WEI)、(Chih-Yung Chiou)、(Shiow-Shuh Chuang)、(Jui-Yung Yang)、李光申(LEE KUANG-SHENG)*,Combination of mesenchymal stem cell-conditioned medium and botulinum toxin type A for treating human hypertrophic scars: Reply,Journal of Plastic Reconstructive and Aesthetic Surgery,2020 Sep,4(7): | 2020 . 09 |
23 | 胡靜暄(Ching-Hsuan Hu)、(Yi-Wen Tseng)、李建緯(LEE CHIEN-WEI)、(Chih-Yung Chiou)、(Shiow-Shuh Chuang)、(Jui-Yung Yang)、李光申(LEE KUANG-SHENG)*,Combination of mesenchymal stem cell-conditioned medium and botulinum toxin type A for treating human hypertrophic scars,Journal of Plastic Reconstructive and Aesthetic Surgery,2020 Mar,73(3):516-527 | 2020 . 03 |
24 | (Hong-Tao Xu)、李建緯(LEE CHIEN-WEI)、(Ming-Yan Li)、(Yu-Fan Wang)、(Patrick Shu-Hang Yung)、李光申(LEE KUANG-SHENG)*,The shift in macrophages polarisation after tendon injury: A systematic review,Journal of Orthopaedic Translation,2020 Mar,21(2020):24-34 | 2020 . 03 |
25 | 李建緯(LEE CHIEN-WEI)、陳瑜帆(CHEN YU-FAN)、(Hao-Hsiang Wu)、李光申(LEE KUANG-SHENG)*,Historical Perspectives and Advances in Mesenchymal Stem Cell Research for the Treatment of Liver Diseases,Gastroenterology,2018 Jan,154(1):46-56 | 2018 . 01 |
26 | 李建緯(LEE CHIEN-WEI)、(Wei-Chih Huang)、(Hsien-Da Huang)、(Yi-Hsiang Huang)、(Jennifer H. Ho)、(Muh-Hwa Yang)、(Vincent W. Yang)、李光申(Oscar Kuang-Sheng Lee)*,DNA Methyltransferases Modulate Hepatogenic Lineage Plasticity of Mesenchymal Stromal Cells,Stem Cell Reports,2017 Jul,9(1):247-263 | 2017 . 07 |
27 | 李建緯(LEE CHIEN-WEI)、(Wei-Ting Hsiao)、李光申(Oscar Kuang-Sheng Lee)*,Mesenchymal stromal cell-based therapies reduce obesity and metabolic syndromes induced by a high-fat diet,Translational Research,2017 Apr,182():61-74 | 2017 . 04 |
28 | (Marilyn G. Rimando)、(Hao-Hsiang Wu)、(Yu-An Liu)、李建緯(LEE CHIEN-WEI)、(Shu-Wen Kuo)、(Yin-Ping Lo)、(Kuo-Fung Tseng)*、(Yi-Shiuan Liu)*、李光申(Oscar Kuang-Sheng Lee)*,Glucocorticoid receptor and Histone deacetylase 6 mediate the differential effect of dexamethasone during osteogenesis of mesenchymal stromal cells (MSCs),Scientific Reports,2016 Nov,6(37371): | 2016 . 11 |
研討會論文
暫無資料專書
暫無資料研究計畫
研究計畫/Research Grant (研究類型,研究計畫代號,主持人,補助或委託單位名稱,計畫名稱,計畫期間) |
日期 | |
1 | 個別型,EXO-113-103,李光申(Oscar Kuang-Sheng Lee)、李建緯(LEE CHIEN-WEI)、陳瑜帆(CHEN YU-FAN),附醫院內計畫,間質幹細胞外泌體治療動脈粥狀硬化之產品開發,2024.1.1~2024.12.31 | 2024 . 01 |
2 | 個別型,NSTC 111-2320-B-039-070-MY3,李光申(Oscar Kuang-Sheng Lee),科技部,銀杏內酯 B 及其與運動鍛鍊聯合介入作為抗衰老治療的探討與機轉研究,2023.9.1~2024.8.31 | 2023 . 09 |
3 | 個別型,DMR-113-069,李建緯(LEE CHIEN-WEI)、陳瑜帆(CHEN YU-FAN)、吳浩翔(WU HAO-HSIANG),附醫院內計畫,人源化肝臟微流控系統之建立,2023.8.1~2024.7.31 | 2023 . 08 |
4 | 個別型,NSTC 112-2320-B-038-020,莊健盈(Jian-Ying Chuang)、李建緯(LEE CHIEN-WEI),科技部,建立Rrm2b基因剔除小鼠模式用以研究中樞神經系統星狀膠質細胞增多症,2023.8.1~2024.7.31 | 2023 . 08 |
5 | 個別型,EXO-113-103,李建緯(LEE CHIEN-WEI)、陳瑜帆(CHEN YU-FAN)、吳浩翔(WU HAO-HSIANG),附醫院內計畫,開發利用間質幹細胞外泌體於毛髮再生之治療策略,2023.8.1~2024.7.31 | 2023 . 08 |
6 | 個別型,DMR-113-106,,附醫院內計畫,醫源性肌肉萎縮的新治療策略:激素賦能間質幹細胞的治療潛力,2023.8.1~2024.7.31 | 2023 . 08 |
7 | 整合型項下子計畫(主持人),NSTC 112-2321-B-A49-014,李建緯(LEE CHIEN-WEI)、陳瑜帆(CHEN YU-FAN)、吳浩翔(WU HAO-HSIANG),科技部,開發人工智慧驅動之人源化肝臟晶片系統用於非酒精性脂肪肝炎之藥物開發與藥物之肝毒性毒理學測試-開發人工智慧驅動之人源化肝臟晶片系統用於非酒精性脂肪肝炎之藥物開發與藥物之肝毒性毒理學測試,2023.6.1~2024.5.31 | 2023 . 06 |
8 | 整合型項下子計畫(主持人),C1110831002-4,李建緯(LEE CHIEN-WEI)、陳瑜帆(CHEN YU-FAN),附醫院內計畫,發展間質幹細胞外泌體治療嚴重急性呼吸系統綜合症,2023.1.1~2023.12.31 | 2023 . 01 |
9 | 整合型項下子計畫(主持人),EXO-112-003,李建緯(LEE CHIEN-WEI)、陳瑜帆(CHEN YU-FAN),附醫院內計畫,開發注射式藥用外泌體緩釋水凝膠產品用於骨關節炎治療,2022.10.1~2023.9.30 | 2022 . 10 |
10 | 個別型,NSTC 111-2320-B-039-070-MY3,李光申(Oscar Kuang-Sheng Lee),科技部,銀杏內酯 B 及其與運動鍛鍊聯合介入作為抗衰老治療的探討與機轉研究,2022.9.1~2023.8.31 | 2022 . 09 |
11 | 個別型,DMR-112-147,,附醫院內計畫,開發三維水凝膠封裝人類脂肪幹細胞外泌體用於促進跟腱再生,2022.8.1~2023.7.31 | 2022 . 08 |
12 | 個別型,DMR-112-171,李光申(Oscar Kuang-Sheng Lee)、李建緯(LEE CHIEN-WEI)、陳瑜帆(CHEN YU-FAN),附醫院內計畫,利用搭載外泌體的水凝膠用於治療小鼠的骨關節炎,2022.8.1~2023.6.30 | 2022 . 08 |
專利技術
專利/Patent (專利名稱,專利類別,專利國別,專利號碼,專利期間) |
日期 | |
1 | 衍生自間質幹細胞之外泌體用於治療非酒精性脂肪性肝炎之用途,發明專利,亞洲、台灣,I836656,2024.3.21~2042.10.5 | 2024 . 03 |
2 | 衍生自間質幹細胞之外泌體用於治療非酒精性脂肪性肝炎之用途,發明專利,台灣,I836656,2024.3.21~2042.10.5 | 2024 . 03 |