醫師介紹
Doctor Introduction
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個人介紹
相關連結
學術論文
期刊論文
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期刊論文／Journal Paper (作者群，論文題目，期刊名稱，出版年月，卷號(期別):頁次起迄) |
日期 | |
| 1 | 高暐翔(KAO WEI-HSIANG)、(Kun-Yuan Chiu)、(Stella Chin-Shaw Tsai)、(Chieh-Lin Jerry Teng)、(Muhammet Oner)、(Chih-Ho Lai)、(Jer-Tsong Hsieh)、(Chi-Chien Lin)、(Hsin-Yi Wang)、陳美智(CHEN MEI-CHIH)*、(Ho Lin)*，PI3K/Akt inhibition promotes AR activity and prostate cancer cell proliferation through p35-CDK5 modulation，BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE，2025 Feb，1871(2):1676568 | 2025 . 02 |
| 2 | 林彥宏、(Chen Y)、劉恩瑋(En-Wei Liu)、陳美智(CHEN MEI-CHIH)、余旻樺(YU MIN-HUA)、陳正祐(CHEN CHENG-YU)、(Ho CC)、許姜太懿(Xu-Jiang,Tai-Yi)、李建智(LEE JIAN-JR)*、周德陽(Der-Yang Cho)*、謝明佑(Ming-You Shie)*，Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing，JOURNAL OF NANOBIOTECHNOLOGY，2025 Jan，23():45 | 2025 . 01 |
| 3 | 林育全(Yu-Chuan Lin)、陳美智(CHEN MEI-CHIH)、黃士維(Shi-Wei Huang)、陳曄(Yeh Chen)、何慧君(HO HUI-CHUN)、林芳妤(Fang-Yu Lin)、陳筱彤(TAN XIAO TONG)、江宏哲(Hung Che Chiang)、黃秋錦(Chiu-Ching Huang)、涂智彥(Chih-Yen Tu)、周德陽(Der-Yang Cho)*、邱紹智(Shao-Chih Chiu)*，Targeting Dual Immune Checkpoints PD-L1 and HLA-G by Trispecific T Cell Engager for Treating Heterogeneous Lung Cancer，Advanced Science，2024 Sep，2024(Sep 5): | 2024 . 09 |
| 4 | (Muhammet Oner)、陳美智(CHEN MEI-CHIH)、(Pang-Ting Cheng)、(Ho Lin)*，Metformin inhibits nerve growth factor (NGF)-induced sympathetic neuron differentiation through p35/CDK5 inhibition，AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY，2024 Jun，326(6):C1648-C1658 | 2024 . 06 |
| 5 | (Muhammet Oner)、陳美智(CHEN MEI-CHIH)、(Pang-Ting Cheng)、黎喻暄(Li, Yu-Hsuan)、(Yu-Chiao Cheng)、(Ayse Celik)、(Shiuan-Woei Soong)、(Li-Wen Hsu)、(Din-You Lin)、(G.M. Shazzad Hossain Prince)、(Trayee Dhar)、(Hsu-Chen Cheng)、(Pin-Chi Tang)、(Ho Lin)*，Impact of metformin on neocortical development during pregnancy: Involvement of ERK and p35/CDK5 pathways，Chemosphere，2024 Apr，358(2024):142124 | 2024 . 04 |
| 6 | (Muhammet Oner)、(Pang-Ting Cheng)、(Hsin-Yi Wang)、陳美智(CHEN MEI-CHIH)、(Ho Lin)*，Metformin alters dendrite development and synaptic plasticity in rat cortical neurons，BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS，2024 Mar，710(2024):149874 | 2024 . 03 |
| 7 | (Muhammet Oner)、(Eugene Lin)、(Kun-Yuan Chiu)、陳美智(CHEN MEI-CHIH)、(G. M. SHAZZAD HOSSAIN PRINCE)、(CHIH-HO LAI)、(JER-TSONG HSIEH)、(HSIN-YI WANG)、(HO LIN)*，p35/CDK5 Regulates Bladder Cancer Proliferation and Migration and Promotes Higher Tumor Grade and Poor Survival Rate in Patients With Bladder Cancer，ANTICANCER RESEARCH，2024 Feb，44(2):543-553 | 2024 . 02 |
| 8 | (Chieh-Lin Jerry Teng)、(Pang-Ting Cheng)、(Yu-Chiao Cheng)、(Jia-Rung Tsai)、陳美智(CHEN MEI-CHIH)、(Ho Lin)*，Dinaciclib inhibits the growth of acute myeloid leukemia cells through either cell cycle-related or ERK1/STAT3/MYC pathways，TOXICOLOGY IN VITRO，2024 Jan，(96): | 2024 . 01 |
| 9 | (Liao, Wan-Ling)、(Ho Lin)、黎喻暄(Li, Yu-Hsuan)、(Tsung-Ying Yang)、陳美智(CHEN MEI-CHIH)*，RAGE potentiates EGFR signaling and interferes with the anticancer effect of gefitinib on NSCLC cells，AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY，2023 Sep，2023(): | 2023 . 09 |
| 10 | 黃士維、潘志明(Chih-Ming Pan)、林育全、陳美智(CHEN MEI-CHIH)、陳曄、詹佳穎、吳仲峻(WU CHUNG CHUN)、林芳妤(Fang-Yu Lin)、王馨葶、林宸宇(Chen-Yu Lin)、林佩瑩(LIN PEI-YING)、黃偉翔、蔣郁亭(Chiang, Yu-Ting)、蔡宛臻(Wan-Chen Tsai)、邱雅煦(CHIU YA-HSU)、林庭熏(Ting-Hsun, Lin)、邱紹智(Shao-Chih Chiu)*、周德陽(Der-Yang Cho)*，BiTE-secreting CAR-γδT as a dual targeting strategy for the treatment of solid tumors，Advanced Science，2023 Jun，10(17):e2206856. | 2023 . 06 |
| 11 | 陳美智(CHEN MEI-CHIH)、洪孟愉、潘志明(Chih-Ming Pan)、黃士維(Shi-Wei Huang)、詹佳穎(Chia-Ing Jan)、黎喻暄(Li, Yu-Hsuan)、邱紹智(Shao-Chih Chiu)*、周德陽(Der-Yang Cho)*，Pemetrexed combined with dual immune checkpoint blockade enhances cytotoxic T lymphocytes against lung cancer，CANCER SCIENCE，2023 Apr，(): | 2023 . 04 |
| 12 | 陳美智(CHEN MEI-CHIH)、(Bing-Ze Yang)、郭薇雯(Kuo, Wei-Wen)、吳世欣(Wu, Shih-Hsin)、(Tso-Fu Wang)、(Yu-Lan Yeh)、(Ming-Cheng Chen)*、黃志揚(Chih-Yang Huang)*，The involvement of Aurora-A and p53 in oxaliplatin-resistant colon cancer cells，JOURNAL OF CELLULAR BIOCHEMISTRY，2023 Mar，2023():1-14 | 2023 . 03 |
| 13 | (Chieh-Yin Chen)、黎喻暄(Li, Yu-Hsuan)、(Wan-Ling Liao)、(Muhammet Oner)、(Yu-Chiao Cheng)、(Fang-Ling Liu)、(Pang-Ting Cheng)、(Ayse Celik)、(Jyh-Horng Wu)、(Chih-Ho Lai)、(Jer-Tsong Hsieh)、(Ho Lin)、(Ting-Chieh Chang)、(Chih-Ying Chang)、陳美智(CHEN MEI-CHIH)*，Antrodia salmonea extracts regulate p53-AR signaling and apoptosis in human prostate cancer LNCaP cells，Evidence-based Complementary and Alternative Medicine，2022 Nov，2022(): | 2022 . 11 |
| 14 | (Pang-Ting Cheng)、(Yu-Chiao Cheng)、(Muhammet Oner)、(Yu-Hsuan Li)、陳美智(CHEN MEI-CHIH)、(Jyh-Horng Wu)、(Ting-Chieh Chang)、(Ayse Celik)、(Fang-Ling Liu)、(Hsin-Yi Wang)、(Hsin-Yi Wang)、(Jer-Tsong Hsieh)、(Chieh-Yin Chen)*、(Ho Lin)*，Antrodia salmonea Extract Inhibits Cell Proliferation through Regulating Cell Cycle Arrest and Apoptosis in Prostate Cancer Cell Lines.，CHINESE JOURNAL OF PHYSIOLOGY，2022 Aug，65(4):209-214 | 2022 . 08 |
| 15 | (Chia-Herng Yue)、(Muhammet Oner)、(Chih-Yuan Chiu)、陳美智(CHEN MEI-CHIH)、(Chieh-Lin Teng)、(Hsin-Yi Wang)、(Jer-Tsong Hsieh)、(Chih-Ho Lai)、(Ho Lin)*，RET Regulates Human Medullary Thyroid Cancer Cell Proliferation through CDK5 and STAT3 Activation，Biomolecules，2021 Jun，2021(11):860 | 2021 . 06 |
| 16 | (Ming?Cheng Chen)、(Do Chi Nhan)、(Chiung?Hung Hsu)、(Tso?Fu Wang)、(Chi?Cheng Li)、(Tsung?Jung Ho)、(B. Mahalakshmi)、陳美智(CHEN MEI-CHIH)*、楊良友(Liang-Yo Yang)*、黃志揚(Chih-Yang Huang)*，SENP1 participates in Irinotecan resistance in human colon cancer cells，JOURNAL OF CELLULAR BIOCHEMISTRY，2021 May，(): | 2021 . 05 |
| 17 | (Wei-Chung Hsu)、(Hang-Nga Le)、(Yu-Jung Lin)、(Ming-Cheng Chen)、(Tso-Fu Wang)、(Chi-Cheng Li)、郭薇雯(Wei-Wen Kuo)、(B Mahalakshmi)、(Chaouhan Hitesh Singh)、陳美智(CHEN MEI-CHIH)*、黃志揚(Chih-Yang Huang)*，Calmodulin/CaMKII-γ mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway，JOURNAL OF CELLULAR BIOCHEMISTRY，2021 Jan，2021():1-14 | 2021 . 01 |
| 18 | 陳美智(CHEN MEI-CHIH)、(Kun-Chieh Chen)、(Gee-Chen Chang)、(Ho Lin)、(Chun-Chi Wu)、(Wei-Hsiang Kao)、(Chieh-Lin Jerry Teng)、(Shih-Lan Hsu)、(Tsung-Ying Yang)*，RAGE acts as an oncogenic role and promotes the metastasis of human lung cancer，Cell Death & Disease，2020 Apr，11(4):265 | 2020 . 04 |
| 19 | (G. M. Shazzad Hossain Prince)、(Tsung?Ying Yang)、(Ho Lin1)*、陳美智(CHEN MEI-CHIH)*，Mechanistic Insight of Cyclin‑Dependent Kinase 5 in Modulating Lung Cancer Growth，CHINESE JOURNAL OF PHYSIOLOGY，2019 Nov，62(6):231-240 | 2019 . 11 |
| 20 | (Muhammet Oner)、林育慶(Eugene Lin)、陳美智(CHEN MEI-CHIH)、許馥甯(Fu-Ning Hsu)、(G M Shazzad Hossain Prince)、裘坤元(Kun-Yuan Chiu)、騰傑林(Chieh-Lin Jerry Teng)、楊宗穎(Tsung-Ying Yang)、王欣怡(Hsin-Yi Wang)、余長澤(Chia-Herng Yue)、余家珩(Ching-Han Yu)、賴志和(Chih-Ho Lai)、謝哲宗(Jer-Tsong Hsieh)、林赫(Ho Lin)*，Future Aspects of CDK5 in Prostate Cancer: From Pathogenesis to Therapeutic Implications，INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES，2019 Aug，20(16): | 2019 . 08 |
| 21 | 傅建堯(Fu, Chien-Yao)、陳美智(CHEN MEI-CHIH)、(Yan-Shen Tseng)、(Ming-Cheng Chen)、(Zhengtao Zhou)、(Jaw-Ji Yang)、(Yueh-Min Lin)、(Vijaya P. Viswanadha)、(Guiqing Wang)、黃志揚(Chih-Yang Huang)*，Fisetin activates Hippo pathway and JNK/ERK/AP-1 signaling to inhibit proliferation and induce apoptosis of human osteosarcoma cells via ZAK overexpression，ENVIRONMENTAL TOXICOLOGY，2019 May，(): | 2019 . 05 |
| 22 | (Chih-Hsiang Chang)、陳美智(CHEN MEI-CHIH)、(Te-Huan Chiu)、(Yu-Hsuan Li)、(Wan-Chen Yu)、(Wan-Ling Liao)、(Muhammet Oner)、(Chang-Tze Ricky Yu)、(Chun-Chi Wu)、(Tsung-Ying Yang)、(Chieh-Lin Jerry Teng)、(Kun-Yuan Chiu)、(Kun-Chien Chen)、(Hsin-Yi Wang)、(Chia-Herng Yue)、(Chih-Ho Lai)、(Jer-Tsong Hsieh)、(Ho Lin)*，Arecoline Promotes Migration of A549 Lung Cancer Cells through Activating the EGFR/Src/FAK Pathway，Toxins，2019 Apr，11(4): | 2019 . 04 |
研討會論文
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研討會論文／Conference Papers (發表主題或論文名稱，研討會名稱，演講地點，研討會期間，受邀演講題目) |
日期 | |
| 1 | Exemestane inhibits survival and cell cycle regulators and retards AML cell proliferation，2023 AACR Special Conference: AML and Myelodysplastic Syndrome，Hyatt Regency Austin in Austin, TX.，2023.01.23~2023.01.25， | 2023 . 01 |
| 2 | Regulation of protein level and subcellular localization of p53 and Aurora A upon UVC treatment in LNCaP cells，第36屆生物醫學聯合學術年會The 36th Joint Annual Conference of Biochemical Science，Taipei, Taiwan.，2022.03.26~2022.03.27， | 2022 . 03 |
| 3 | Detecting suspended A549 lung cancer cells by 3D hollow SERS active magnetic nanoparticles using cell surface RAGE protein as a target.，第36屆生物醫學聯合學術年會The 36th Joint Annual Conference of Biochemical Science, Taipei, Taiwan.，Taipei, Taiwan.，2022.03.26~2022.03.27， | 2022 . 03 |
| 4 | The effects of ultraviolet c on the regulation of Aurora A and p53 proteins in prostate cancer LNCaP cells，The 1st International Electronic Conference on Cancers，online，2021.02.1 ~2021.02.14， | 2021 . 02 |
| 5 | The effects of Antrodia salmonea extracts on androgen receptor inhibition and LNCaP cell apoptosis，The 1st International Electronic Conference on Toxins，online，2021.01.16~2021.01.31， | 2021 . 01 |
| 6 | CDK5 down-regulates p21expression through inhibiting STAT3，The 2019 Federation of the Asian and Oceanian Physiological Societies Congress，日本，2019.03.28~2019.03.31， | 2019 . 03 |
| 7 | CaM upregulation in HDACi-resistant cells activates multiple downstream protein promote cell resist to drug in Hepatocellular carcinoma cells，第34屆生物醫學聯合學術年會，國防醫學院，2019.03.23~2019.03.24， | 2019 . 03 |
| 8 | IL-6 promotes CDK5-induced STAT3/androgen receptor activation in prostate cancer cells，The 2019 Federation of the Asian and Oceanian Physiological Societies Congress，日本，2019.03.28~2019.03.31， | 2019 . 03 |
| 9 | The inhibitory effects of microRNA-107 on p35/CDK5-regulated prostate cancer cell growth，The 2019 Federation of the Asian and Oceanian Physiological Societies Congress，日本，2019.03.28~2019.03.31， | 2019 . 03 |
| 10 | CDK5 regulates estrogen receptor and breast cancer cell growth，The 2019 Federation of the Asian and Oceanian Physiological Societies Congress，日本，2019.03.28~2019.03.31， | 2019 . 03 |
| 11 | CDK5 promotes androgen receptor transactivation under Akt inhibition stress，The 2019 Federation of the Asian and Oceanian Physiological Societies Congress，日本，2019.03.28~2019.03.31， | 2019 . 03 |
| 12 | Dinaciclib inhibits Aurora A expression and proliferation of prostate cancer cells.，The 2019 Federation of the Asian and Oceanian Physiological Societies Congress，日本，2019.03.28~2019.03.31， | 2019 . 03 |
| 13 | The inhibitory effects of valproic acid on androgen receptor and prostate cancer cell growth，The 2019 Federation of the Asian and Oceanian Physiological Societies Congress，日本，2019.03.28~2019.03.31， | 2019 . 03 |
| 14 | Synergistic inhibition of Dinaciclib and Paclitaxel on breast cancer cell growth，The 2019 Federation of the Asian and Oceanian Physiological Societies Congress，日本，2019.03.28~2019.03.31， | 2019 . 03 |
| 15 | The role of SUMO1 Specific Peptidase 1 in irinotecan resistant LoVo colorectal cancer cells，第34屆生物醫學聯合學術年會，國防醫學院，2019.03.23~2019.03.24， | 2019 . 03 |
| 16 | Synergistic effect of metformin and emodin on the stability and expression of androgen receptor protein in LNCaP，The 2018 annual meeting of Asia Pacific Society for Biology and Medical Sciences，日本，2018.07.19~2018.07.22， | 2018 . 07 |
專書
暫無資料研究計畫
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研究計畫／Research Grant (研究類型，研究計畫代號，主持人，補助或委託單位名稱，計畫名稱，計畫期間) |
日期 | |
| 1 | 個別型，MOST 110-2320-B-039-012-MY3，，科技部，探討RAGE對EGFR訊息路徑的調控及其交互作用對癌細胞的影響，2023.8.1~2024.7.31 | 2023 . 08 |
| 2 | 個別型，DMR-112-137，周德陽(Der-Yang Cho)，附醫院內計畫，探討pemetrexed聯合抗PD-L1免疫檢查點阻斷對HLA-G-CAR-γδT細胞毒殺非小細胞肺癌的影響，2022.8.1~2023.7.31 | 2022 . 08 |
| 3 | 個別型，MOST 110-2320-B-039-012-MY3，，科技部，探討RAGE對EGFR訊息路徑的調控及其交互作用對癌細胞的影響，2022.8.1~2023.7.31 | 2022 . 08 |
| 4 | 個別型，MOST 110-2320-B-039-012-MY3，，科技部，探討RAGE對EGFR訊息路徑的調控及其交互作用對癌細胞的影響，2021.8.1~2022.7.31 | 2021 . 08 |
| 5 | 個別型，DMR-110-138，周德陽(Der-Yang Cho)，附醫院內計畫，HLA-G作為特異性靶標嵌合抗原受體（CAR）工程T細胞療法用於治療非小型細胞肺癌的可行性，2020.8.1~2021.7.31 | 2020 . 08 |
| 6 | 個別型，CMU108-MF-92，，本校(含附醫)，探討在Irinotecan 抗藥性大腸癌細胞中SUMO特異性蛋白酶1(SENP1)和SUMOylation調節HIF-1α的作用，2019.9.9~2020.7.31 | 2019 . 09 |
| 7 | 個別型，MOST 108-2320-B-039-008，黃志揚(Chih-Yang Huang)，科技部，探討在Irinotecan 抗藥性大腸癌細胞中SUMO特異性蛋白酶1(SENP1)和SUMOylation調節HIF-1α的作用，2019.8.1~2020.7.31 | 2019 . 08 |
| 8 | 個別型，DMR-108-171，黃志揚(Chih-Yang Huang)，附醫院內計畫，探討Aurora A在Dinaciclib抑制前列腺癌細胞生長中的作用，2018.8.1~2019.6.30 | 2018 . 08 |
專利技術
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專利／Patent (專利名稱，專利類別，專利國別，專利號碼，專利期間) |
日期 | |
| 1 | FUSION PROTEINANDNUCLEICACID ENCODING SEQUENCETHEREOF,AND USES OFTHESAME，發明專利，美國、台灣、日本，US12221483B1，2024.1.30~2044.1.29 | 2024 . 01 |
| 2 | 多特異性單域抗體嵌合抗原受體及T細胞銜接體、核酸、其表達細胞、其用途以及治療癌症之醫藥組合物，發明專利，台灣，I823402，2023.11.21~2042.5.22 | 2023 . 11 |
| 3 | IMMUNOMODULATIONAND ANTI-TUMOR-RELATEDNANOBODYAND NUCLEIC ACID ENCODING SEQUENCE THEREOF,AND USES OF THE SAME，發明專利，美國，US11795227B2，2023.10.24~2043.10.23 | 2023 . 10 |
| 4 | 抗腫瘤抗原奈米抗體暨其核酸編碼序列及其應用，發明專利，台灣，I799205，2023.4.11~2042.3.22 | 2023 . 04 |
| 5 | 抗-T細胞奈米抗體暨其核酸編碼序列及其應用，發明專利，台灣，I792955，2023.2.11~2042.3.22 | 2023 . 02 |
| 6 | 免疫調控奈米抗體暨其核酸編碼序列及其應用，發明專利，台灣，I790150，2023.1.11~2042.3.22 | 2023 . 01 |
獲獎事蹟
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獲獎／Award (獲獎名稱，給獎單位，獲獎日期) |
日期 | |
| 1 | 2023 未來科技獎，科技部，2023.10.14 | 2023 . 10 |
技術轉移
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技術轉移／Technology Transfer (技術名稱，發明人，合約期間，專利名稱，授權單位，授權單位名稱) |
日期 | |
| 1 | 雙特異性T細胞銜接奈米抗體治療平台，邱紹智(Shao-Chih Chiu)、周德陽(Der-Yang Cho)、黃士維、潘志明(Chih-Ming Pan)、陳美智(CHEN MEI-CHIH)、吳仲峻(WU CHUNG CHUN)、林育全，2021.7~2041.7，，本校(含附醫)，聖安生醫股份有限公司 | 2021 . 07 |
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