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Adcetris® is an antibody-drug conjugate combining a cytotoxic agent with a selective monoclonal antibody, which targets a protein called CD30 on the surface of some lymphoma cells, and delivers a cytotoxic agent to destroy the cancer cells.
Busulfan is an alkylating agent that exerts its anticancer activity by reacting with DNA and interfering with DNA replication and cell division. This stops the growth and spread of cancer cell in the body.
Cabazitaxel is a synthetic analogue of taxane, a nature product derived from the needles of the European yew tree. This medicine inhibits the action of proteins called microtubules for cell division, thus stopping cancer cells from separating into two new cells, eventually causing cell death.
Carfilzomib is a proteasome inhibitor. A proteasome is an enzyme that is responsible for breaking down proteins in cells. By blocking the action of proteasome, waste proteins build up in myeloma cells, and cause them to die.
Clofarabine is classified as an anticancer antimetabolites. This medicine inhibits ribonucleotide reductase that is essential for the formation of DNA and RNA. This stops the growth of cancer cells, causing the cells to die.
Dactinomycin is classified as an anticancer antibiotic. This medicine inhibits DNA and RNA synthesis, thus stopping cell replication and eventually cause cell death. This cell damage slows or stops the growth of cancer cells in the body.
Darzalex® is a monoclonal antibody that targets to the protein called CD38, which is highly expressed on multiple myeloma cells. Once Darzalex® attaches to CD38, it induces rapid cell death and activates the immune system to destroy the myeloma cells.
Daunorubicin is classified as an anthracyline antibiotic. This medicine inhibits DNA synthesis by producing DNA cross-links which halt cell replication and eventually cause cell death. This cell damage slows or stops the growth of cancer cells in the body.
Atezolizumab is a monoclonal antibody that binds to PD-L1 (programmed cell death ligand 1) and blocks its interaction with PD-1 (programmed cell death 1 receptor).