Trade name

Tecentriq^®

What Atezolizumab is and what it is used for?

• Atezolizumab is a monoclonal antibody that binds to PD-L1 (programmed cell death ligand 1) and blocks its interaction with PD-1 (programmed cell death 1 receptor). PD-1 is a checkpoint protein on T cells that prevents the immune system from attacking other cells in the body.PD-L1 is a protein expressed in both normal and tumor cells. When tumor PD-L1 binds to T cell PD-1, T cell activation is inhibited, thus blocking the normal immune response to tumor cells. This medicine blocks the activity of PD-L1 and enhances the immune response against cancer cells. 
• Atezolizumab can be used either alone or with other anti-cancer medicines. This medicine usually is given after other cancer treatments did not work or is no longer working. This medicine is indicated for the treatment of patients with bladder and urinary tract cancer, breast cancer, lung cancer and liver cancer that has spread to other parts of the body, or cannot be removed by surgery.
• Atezolizumab works in patients whose tumor tested positive for PD-L1.Your doctor will perform a PD-L1 testing to determine if this medicine is right for you.

How Atezolizumab is given?

• It is given as an infusion into a vein over an hour. The time of the infusion may be shortened to 30 minutes depending on how well you tolerate this drug after the first infusion.

What should I know while receiving Atezolizumab?

• Infusion reactions may happen during or shortly after the infusion, causing fever, chills, itching or rash, back or neck pain, facial swelling, flushing, breathing difficulties, or dizziness. Tell your nurse right away if you feel unwell during an infusion.
• Do not receive this drug when you are pregnant. Effective contraception should be used during treatment and for at least 5 months after the last dose.
• Do not breastfeed during treatment and for at least 5 months after the last dose.
• Do not receive any kind of vaccination without doctor's approval.
• You will have regular blood tests to check that you have enough blood cells and have adequate organ functions to receive this drug. The timing of your treatment may be changed based on the test results or other side effects.
• The existing health problems may affect the use of atezolizumab. You should let your doctor know if you have any other medical problems, especially if you have an autoimmune disease, or have any types of infections.
• There are many drugs may affect how atezolizumab works, especially medicines which can weaken your immune system. Tell your doctor about all the medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Common side effects

• Weakness and fatigue

Try to pace yourself and rest as much as possible. Seek medical advice if fatigue does not go away when you rest and sleep.

Less common side effects

• Loss of appetite

Try to eat in small quantities and have frequent meals. If your appetite does not get any better after a few days, tell your doctor.

• Diarrhea or constipation

Talk to your doctor and ask for advice. Drinking plenty of water and dietary changes can improve symptoms.

• Nausea

Medicines may be given before the treatment to prevent it happening. Eating and drinking often in small amounts may reduce the discomfort.

• Muscle or joint pain

The pain is usually mild. Talk to the doctor if this is bothering you, they can give you medicine to relieve pain.

• Skin rash

A rash can be itchy, red, or painful. Tell your doctor about any skin changes that you have, they can give you medicines and advices that help you feel better.

• Flu-like symptoms

Symptoms such as fever, headache, muscle pains and shivering may occur a few hours after treatment. These symptoms generally last for 2 to 3 days. Seek medical help if you do not get any better.

Uncommon but important side effects

Atezolizumab can cause your immune system to attack healthy organs and can affect the way they work. These problems can occur at any time during or even after treatment is over and can range from mild to life-threatening. Not all potential side effects are listed below. Seek medical help right away if you have any new or worsening symptoms.

• Inflammation of the lungs

Contact your doctor right away if you notice a new or worsening cough, shortness of breath or chest pain.

• Inflammation of the liver

Seek medical help right away if you have yellowing of the skin or eyes, dark or brown urine, or pain in abdomen, as these can be signs that your liver is not working well.

• Inflammation of kidney

Seek medical help at once if you have trouble urinating, decreased urination, swelling in limbs, a big weight gain, or pain in lower back.

• Hormone gland problems (such as thyroid, adrenal glands, pancreas, and pituitary)

The problems depend on which hormone glands are affected. Common signs and symptoms may include changes in mental status, nausea and vomiting, weakness, feeling cold, missed or no menstrual periods, passing urine more often than usual, weight loss or gain. Contact your doctor if you have any possible signs of an endocrine problem.

• Inflammation of the eyes

Seek medical help right away if you have problems with vision, eye pain or redness while receiving atezolizumab.

• Inflammation of the bowel

Contact your doctor immediately if you have persistent watery or bloody diarrhea, or have severe abdominal pain.

More Information

• Drink at least 6 to 8 glasses of water every day during treatment can help make your recovery a smoother process.
• Alcohol and cigarettes may interfere with certain medicines or worsen side effects from chemotherapy treatment. It is wise to avoid alcohol and cigarette smoking during cancer treatment. If you have any problem about drinking alcohol and smoking, you should check with your doctor.