Health Information

Health Education

:::

Comparison of Various Down Syndrome Tests 各種唐氏症檢查比較表

Qrcode
Print
A-
A+

Comparison of Various Down Syndrome Tests 各種唐氏症檢查比較表

2024/1/31

Down syndrome occurs when a baby is born with an extra chromosome 21, leading to intellectual disability and congenital heart disease. The older the woman, the more likely she is to have a Down's baby. Doctors would recommend that pregnant women be screened for Down syndrome. The following is a comparison of Down syndrome tests:

Method
Test name and method
Weeks
Detection rate of Sown syndrome
Specimens
Pros and cons
Non-invasive
1. First trimester screening (Investigation of the zona pellucida by ultrasound + maternal blood sampling)
11-13 weeks
90-91%
(Plus measurement of fetal nasal bone)
Maternal serum
Pros: Ultrasound including early fetal structural examination.
Cons: Ultrasound technology has a high threshold and requires additional exam time, and the detection rate is limited.
Non-invasive
2. Second trimester screening
(Four indicators for maternal serum Down syndrome screening )
15-20 weeks
81 %
Maternal serum
Pros: Only maternal blood is needed, and the threshold for testing is low.
Cons: The detection rate is low as the examination weeks are late.
Non-invasive
3. Noninvasive prenatal fetal chromosome testing
(Maternal blood is drawn to test fetal chromosomes)
10 weeks or more
99 %
Maternal-fetal chromosomes
Pros: The testing of Down's syndrome, Edwards syndrome (T18) and Patau syndrome (T13) is accurate and safe.
Cons: It is expensive and the testing items are limited.
Invasive (amniotic fluid extraction)
4. Amniocentesis
(Fetal cells are cultured in amniotic fluid drawn for fetal chromosome analysis)
16-20 weeks
> 99 %
Chromosomes
Pros: Techniques for diagnosis, with the addition of array CGH, are the most complete examination of chromosomes
Cons: The chance of miscarriage is about 1-3/ 1000 for an invasive amniotic cavity examination

 

若有任何疑問,請不吝與我們聯絡
電話:(04) 22052121 分機 12188
HE-60064-E
}
Stay connected with CMUH
How to get to CMUH the map of hospital